Nucleoporin 85

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Nucleoporin 85kDa
Identifiers
Symbols NUP85 ; Nup75
External IDs OMIM170285 MGI3046173 HomoloGene11755 GeneCards: NUP85 Gene
RNA expression pattern
PBB GE NUP85 218014 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79902 445007
Ensembl ENSG00000125450 ENSMUSG00000020739
UniProt Q9BW27 Q8R480
RefSeq (mRNA) NM_024844 NM_001002929
RefSeq (protein) NP_079120 NP_001002929
Location (UCSC) Chr 17:
73.2 – 73.23 Mb
Chr 11:
115.56 – 115.58 Mb
PubMed search [1] [2]

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.[1][2]

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.[2]

Model organisms[edit]

Model organisms have been used in the study of NUP85 function. A conditional knockout mouse line called Nup85tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]



References[edit]

  1. ^ Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Apr 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. 
  2. ^ a b "Entrez Gene: NUP85 nucleoporin 85kDa". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]