Nucleoporin 88

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Nucleoporin 88kDa
Symbols NUP88 ; MGC8530
External IDs OMIM602552 MGI104900 HomoloGene1901 GeneCards: NUP88 Gene
RNA expression pattern
PBB GE NUP88 202900 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4927 19069
Ensembl ENSG00000108559 ENSMUSG00000040667
UniProt Q99567 Q8CEC0
RefSeq (mRNA) NM_002532 NM_001083331
RefSeq (protein) NP_002523 NP_001076800
Location (UCSC) Chr 17:
5.26 – 5.32 Mb
Chr 11:
70.94 – 70.97 Mb
PubMed search [1] [2]

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.[1][2]


The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.[2]


NUP88 has been shown to interact with NUP98.[3]


  1. ^ Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti KG et al. (Mar 1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMC 1169681. PMID 9049309. 
  2. ^ a b "Entrez Gene: NUP88 nucleoporin 88kDa". 
  3. ^ Griffis ER, Xu S, Powers MA (Feb 2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995. PMID 12589057. 

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