Muthuswamy has been described by The Hindu as "the master of the avant-garde". Muthusamy also made his first film appearance in Vaazhththukkal.
Muthuswamy first achieved prominence as a result of the play "Kalam Kalamaga", which has been described as the "first modern play in Tamil". He has won the Sangeet Natak Akademi Award from the Government of India for year 1999. He was awarded the Padma Shiri in 2012.