Naftifine

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Naftifine
Naftifine.svg
Systematic (IUPAC) name
(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
Clinical data
Trade names Naftin
AHFS/Drugs.com monograph
MedlinePlus a688020
Legal status
?
Identifiers
CAS number 65472-88-0 YesY
ATC code D01AE22
PubChem CID 47641
DrugBank DB00735
ChemSpider 66071 N
UNII 4FB1TON47A N
ChEMBL CHEMBL626 N
Chemical data
Formula C21H21N 
Mol. mass 287.398 g/mol
 N (what is this?)  (verify)

Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.[1][2] The half-life is approximately 2–3 days.[2] The metabolites are excreted in the urine and feces.[3]

References[edit]

  1. ^ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
  2. ^ a b Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.
  3. ^ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.