The station is accessible from the east side of Nanaimo Street at Vanness Avenue. It is located on the crest of a hill, providing all riders a wonderful view of Downtown and the west side of Vancouver. Just east of this station, the Skytrain line runs at grade level. Most of the Skytrain line through the next three stations (from Nanaimo, through 29th Avenue, to Joyce) is located at ground level.
The Nanaimo Station was built in 1985 as part of the original Expo Line, and is a connection point for a number of TransLink bus routes in East Vancouver.