Unlike the majority of Haldimand or Norfolk County, Nanticoke is a highly industralized community. Its industries supply up to 4000MW of electric energy to Southern Ontario through the Nanticoke Generating Station. This community is southeast of Simcoe in neighbouring Norfolk County and south of Brantford. Nanticoke's residential area is bordered on the west by the Nanticoke Industrial Park, home to the U. S. Steel Canada Lake Erie Works and a number of smaller businesses, including Nelson Steel, Charles Jones Industrial, ESM, and Air Products. The neighbouring Esso Refinery Nanticoke on the northeast, and the Nanticoke Generating Station on the southeast are not part of the Industrial Park land, although this is frequently confused due to their proximity.
One of Nanticoke's natural landmarks is Peacock Point; which is surrounded by modest working class houses. Camp Guinane is a camping spot that is located near the core of Nanticoke. One of the closest communities to Nanticoke is Jarvis; which is only 11.4 kilometres or 7.1 miles to the north-northeast. There are plenty of streams, valleys, and even a lake within a short driving distance from Nanticoke. Selkirk Provincial Park is approximately 11 kilometres or 6.8 miles away and is the closest provincial park to Nanticoke.
Nanticoke is also the home to one of the world's active seaports; located at .
Once considered to be a bustling farming and fishing community inhabited since the late 18th century, Nanticoke adapted itself to the Industrial Revolution and became a desired spot for heavy industry to move in through the decades.
In 1974, Nanticoke was incorporated as a city within the Regional Municipality of Haldimand-Norfolk through the amalgamation of the towns of Port Dover and Waterford, the village of Jarvis, and parts of the townships of Rainham, Townsend, Walpole and Woodhouse. In 2001, the town and all other municipalities within the region were dissolved and the region was divided into two single tier municipalities with city-status but called counties. What was the city of Nanticoke is now split between Haldimand County (Ward 1) and Norfolk County (Wards 6 and 7).
 Notable people
- Harold Cotton, retired ice hockey player
- Ryan Nie, current ice hockey player in the GET-ligaen professional ice hockey league in Norway
- Nanticoke, Ontario at TravelingLuck.com
- Daniel Pearce (2011). "Green projects receive go-ahead". Brantford Expositor. Retrieved 2012-01-24. "The big news, however, was in Haldimand County. That community was awarded a project that could see up to 100 wind turbines along the lake-shore in the Nanticoke area. As well, the proposal that includes the Port Dover windmills extends into Haldimand, where another 40 or more turbines could be located." mirror