Nasir Hossain was a part of the 13-man Bangladesh squad that played in the 2010 Asian Games in late November. The team played Afghanistan in the final and won by five wickets, gaining the country's first gold medal at the Asian Games. He made his ODI debut on 14 August 2011 against Zimbabwe. Coming in with Bangladesh's score at 58 for 6, the 19-year-old Hossain top-scored for his side with 63 runs from 92 balls, lifting the score to 188. It was not enough, and Zimbabwe won by seven wickets. In the final game of the five-match series, Hossain accidentally injured Zimbabwe fast bowler Keegan Meth. Hossain drove a delivery from Meth straight back and the bowler was unable to get out of the way. He was struck in the mouth, knocking out three teeth.
After losing the ODI series against Zimbabwe 3–2, Bangladesh hosted the West Indies in October for a T20I, three ODIs, and two Tests. In the second ODI, he scored his second half-century. He again came to the wicket with Bangladesh struggling and scored 50 from 54 deliveries. In the final match of the ODI series, which Bangladesh lost 2–1, Hossain took his first wickets in the format. His first was that of left-handed opening batsman Kieran Powell with a delivery that pitched on leg stump and spun to hit the off stump. On a turning pitch Hossain's two wickets for three runs (2/3) helped Bangladesh bowl West Indies out for 61, their second lowest score, and win the match. Starting in November, Pakistantoured Bangladesh. In the second of three ODIs Hossain scored his maiden international century. He scored 100 runs off 134 balls and was selected Man of the Match for his efforts, though Bangladesh found lost. He scored his maiden test century against Sri Lanka at Galle on 11 March 2013. He scored 100 of 151 balls with 9 fours. And in the 1st ODI against Sri Lanka he scored At Sooriyawewa, Hambantota in 23 March 2013 he played a magnificent innings of 73 of 59 ball and he was not out . In 3rd ODI The Bangladesh dugout is ecstatic and it has been a brilliant innings under pressure by Nasir Hossain 33(27b).