Natalie was Jack's Scottish niece who came to stay with her uncle after refusing to go back to the small village she came from. She was blonde and attractive and she knew it. She annoyed Jack's lodger Izzy Davies (Elize du Toit) by stealing her clothes and makeup, and flirting outrageously with her boyfriend Ben Davies. She also proved to be work-shy and,along with cousin Darren,a trouble maker. She made no friends during her time in the village as she was extremely bitchy and was always trying to steal someone else's boyfriend.
Her love life was also unpredictable as she shared a brief love affair and dalliance with cousin Darren but rejected his later advances until he got with Debbie Dean (Jodi Albert) when she began sleeping with him again. Debbie's jealousy led to a ketchup fight between the girls in the pub before Debbie dumped Darren. By this time Natalie did not want him and managed to seduce Craig Dean (Guy Burnett) and he lost his virginity to her. Her treatment of Craig was mean, and she was taught a lesson by Craig's sisters Debbie and Steph Dean (Carley Stenson) who had both had an intense dislike of Natalie since she arrived. She was horrified when her little sister Rachel Osborne (Lucy Evans) arrived and vowed to get rid of her as soon as possible. After weeks of fighting and squabbling, the final straw came when Jack found out about her failing her exams due to the lack of work and also her second pregnancy but not knowing who the father was. Despite using her charms, Jack told Rachel and Natalie that they were being sent home. Rachel was delighted and Natalie flounced off back to Scotland.
Virgin Media profiled some of Hollyoaks' "hottest females" in their opinion, of Natalie they stated: "The claws were out when Jack Osborne's niece, Natalie, landed in Hollyoaks. The sexy madam charmed the pants off many a man during her brief stay but she was unceremoniously sent back to Scotland after getting pregnant."