Nenad Ban

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Nenad Ban
Nenad Ban (Scientist).jpg
Born (1966-05-03) May 3, 1966 (age 48)
Zagreb, Croatia
Residence Switzerland
Nationality Croatia
Fields Biochemistry and Biophysics
Institutions ETH Zurich
Alma mater University of Zagreb, Croatia, University of California at Riverside
Doctoral advisor Alexander McPherson
Other academic advisors Thomas A. Steitz
Known for Structural biology, structure and function of the ribosome, structure and function of multi-enzymes
Notable awards Heinrich Wieland Prize (2012)
Newcomb Cleveland Prize (2001)
Spouse Eilika Weber-Ban

Nenad Ban is a Croatian biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology.

Career[edit]

Nenad Ban was educated at the University of Zagreb and continued with his studies in the US where he obtained a PhD degree at the University of California at Riverside in the laboratory of Alexander McPherson. His interest in large macromolecular assemblies led him for his postdoctoral work to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz. These results demonstrated that the ribosome is a ribozyme.[1]

Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich.[2] (Swiss Federal Institute of Technology). His group is studying structure and function of large cellular assemblies using a combination of crystallographic, electron microscopic and biochemical experiments. Specifically focusing on various ribosomal complexes [3][4] involved in co-translational protein processing,[5][6] folding,[7][8] and targeting.[9][10][11][12]

His group has obtained detailed structural information on eukaryotic ribosomes, which are significantly larger and more complex than their bacterial counterparts, by determining the first complete structures of both eukaryotic ribosomal subunits each in complex with an initiation factor.[13][14] Furthermore, his group investigated giant multifunctional enzymes involved in fatty acid synthesis offer first mechanistic insights into substrate shuttling and delivery in such megasynthases, with direct implications for our understanding of polyketide synthases.[15][16][17][18][19]

Honors[edit]

Nenad Ban is a member of the European Molecular Biology Organization (EMBO), the German Academy of Sciences, the Croatian Academy of Arts and Sciences and the recipient of several prizes and awards including the Heinrich Wieland Prize,[20] Roessler prize of the ETH Zurich,[21] the Latsis prize,[22] the Friedrich Miescher Prize of the Swiss Society for Biochemistry,[23] Spiridon Brusina medal and the AAAS Newcomb Cleveland Prize.[24]

References[edit]

  1. ^ Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science. 2000 Aug 11;289(5481):905-20. PubMed PMID 10937989.
  2. ^ "ETH Zurich: Prof. Nenad Ban". Mol.biol.ethz.ch. 2013-02-05. Retrieved 2013-09-09. 
  3. ^ Greber BJ, Boehringer D, Montellese C, Ban N. (2012) Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit. Nat Struct Mol Biol.(12):1228-33.
  4. ^ Greber BJ, Boehringer D, Godinic-Mikulcic V, Crnkovic A, Ibba M, Weygand-Durasevic I, Ban N. (2012) Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution. J Mol Biol. 2012 Jan 27. [Epub ahead of print]
  5. ^ Nat Struct Mol Biol. 18(1):88-90
  6. ^ Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolić S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N. (2008) A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature 452(7183):108-11
  7. ^ Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins. Nature 431(7008):590-6
  8. ^ Kramer, G., Rauch, T., Rist, W., Vorderwulbecke, S., Patzelt, H., Schulze-Specking, A., Ban, N., Deuerling, E., Bukau, B. (2002). L23 protein functions as a chaperone docking site on the ribosome.
  9. ^ Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. (2011) The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor. Science 331(6019):881-886
  10. ^ Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C. (2010) Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.
  11. ^ Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams JP, Koerten HK, Koning RI and Ban N. (2006) Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature 444(7118):503-6
  12. ^ Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E and Ban N. (2004)
  13. ^ Klinge S, Voigts-Hoffmann F, Leibundgut M, Arpagaus S, Ban N. (2011) Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.Science 334(6058):941-948, Published Online November 3, 2011
  14. ^ Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N. (2010) Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1. Science 331(6018):730-6
  15. ^ Maier T, Leibundgut M, and Ban N (2008) The Crystal Structure of a Mammalian Fatty Acid Synthase. Science 321(5894):1315-22
  16. ^ Leibundgut M, Jenni S, Frick C, Ban N. (2007) Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase. Science 316(5822):288-290
  17. ^ Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N. (2007) Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling. Science 316:(5822):254-261. Pubmed
  18. ^ Maier T, Jenni S, and Ban N. (2006) Architecture of mammalian fatty acid synthase at 4.5 Å resolution. Science 311(5765):1258-62
  19. ^ Jenni S, Leibundgut M, Maier T and Ban N. (2006) Architecture of a fungal fatty acid synthase at 5 Å resolution. Science 311(5765):1263-7
  20. ^ "Heinrich Wieland Prize". Heinrich-wieland-preis.de. 2010-10-28. Retrieved 2013-09-09. 
  21. ^ "ETH Zürich - Archiv 2009". Ethz.ch. Retrieved 2013-09-09. 
  22. ^ "Verleihung des LATSIS-Preises der ETH Zurich selt 1985". Vpf.ethz.ch. Retrieved 2013-09-09. 
  23. ^ scnat.ch. "Awardees". Swissbiochem.ch. Retrieved 2013-09-09. 
  24. ^ "Newcomb Cleveland Prize - Recipients". AAAS. Retrieved 2013-09-09. 

External links[edit]