Nepoviruses or nematode transmitted polyhedral viruses, are a genus of plant viruses of the family Secoviridae and subfamily Comovirinae. Nepoviruses, unlike the other two genera (Comovirus and Fabavirus) in the subfamily Comovirinae, are transmitted by nematodes.
Nepoviruses are classified as type IV viruses under the Baltimore classification system, and consequently contain bipartite, linear, single stranded positive sense RNA genomes. The two genome segments are encapsulated separately into two different icosahedral particles. Each of the genome segments produces a different polypeptide, which undergoes a series of steps (i.e. proteolysis, and other post-translational modifications) in order to produce a functional protein.
The first segment (RNA1) is approximately 8,000 nucleotides in length and appears as a single copy in each B type virion. It encodes the proteins that are important in replication and is the first gene to be activated.
The second segment (RNA2) is approximately 4,000–7,000 nucleotides in length and usually appears as a single copy in each M type virion. It encodes the proteins that are important in cell-cell transmission and evasion of cellular defenses.
There are many members of the genus Nepovirus including the species:
- "Notes on Genus: Nepovirus". Retrieved 2007-08-06.