He was a student of Vecchietta, and then he shared a workshop with Francesco di Giorgio from 1468. He painted Scenes from the life of St Benedict, now in the Uffizi, probably in collaboration with di Giorgio, and a Madonna and Child between Saint Jerome and Saint Bernard, which is in the Pinacoteca of Siena. In 1472 he painted an Assumption for the abbey of Monte Oliveto Maggiore, and in 1475 he created a statue of Saint Catherine of Siena for the Sienese church dedicated to her.
He separated from di Giorgio in 1475. In 1483, he designed the Hellespontine Sybil for the mosaic pavement of the Cathedral of Siena, and the tomb for the Bishop Tommaso Piccolomini del Testa.