Nesprin

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The Nesprins (nuclear envelope spectrin repeat proteins[1]) are a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments.[2] They contain a C-terminal KASH transmembrane domain and are part of the LINC complex (Linker of Nucleoskeleton and Cytoskeleton)which is a protein network that associates the nuclear envelope (the membrane surrounding the nucleus) to the cytoskeleton, outside the nucleus, and the nuclear lamina, inside the nucleus.[3] Nesprin-1 and -2 bind to the actin filaments.[4] Nesprin-3 binds to plectin, which is bound to the intermediate filaments,[5] while nesprin-4 interacts with kinesin-1.[6]

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References[edit]

  1. ^ http://jcs.biologists.org/cgi/content/abstract/114/24/4485
  2. ^ http://dx.doi.org/10.1017/erm.2013.6
  3. ^ Dipen Rajgor and Catherine M. Shanahan (2013). Nesprins: from the nuclear envelope and beyond. Expert Reviews in Molecular Medicine, 15, e5 doi:10.1017/erm.2013.6.
  4. ^ Dipen Rajgor and Catherine M. Shanahan (2013). Nesprins: from the nuclear envelope and beyond. Expert Reviews in Molecular Medicine, 15, e5 doi:10.1017/erm.2013.6.
  5. ^ Wilhelmsen, K; Litjens, SH; Kuikman, I; Tshimbalanga, N; Janssen, H; Van Den Bout, I; Raymond, K; Sonnenberg, A (Dec 2005). "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin" (Free full text). The Journal of Cell Biology 171 (5): 799–810. doi:10.1083/jcb.200506083. ISSN 0021-9525. PMC 2171291. PMID 16330710. 
  6. ^ Roux, KJ; Crisp, ML; Liu, Q; Kim, D; Kozlov, S; Stewart, CL; Burke, B (Feb 2009). "Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization" (Free full text). Proceedings of the National Academy of Sciences of the United States of America 106 (7): 2194–9. doi:10.1073/pnas.0808602106. ISSN 0027-8424. PMC 2650131. PMID 19164528.