|Born||Nettie Maria Stevens
July 7, 1861
|Died||May 4, 1912
|Alma mater||Westfield Normal School
Bryn Mawr College
|Doctoral students||Alice Middleton Boring|
|Known for||XY sex-determination system|
|Influences||Edmund Beecher Wilson; Thomas Hunt Morgan|
Nettie Maria Stevens was born on July 7, 1861. An outstanding student, Nettie Stevens completed in two years the four-year course at Westfield Normal School (now Westfield State University) in Massachusetts.
Stevens continued her studies in cytology at Bryn Mawr, where she was influenced by the work of the previous head of the Biology Department, Edmund Beecher Wilson, and by that of his successor, T. H. Morgan. She also studied marine organisms in Europe, at Helgoland and Naples Zoological Station.
Stevens was one of the first American women to be recognized for her contribution to science. Her research was done in Bryn Mawr College. She discovered that in some species chromosomes are different among the sexes, by observations of insect chromosomes. The discovery was the first time that observable differences of chromosomes could be linked to an observable difference in physical attributes i.e. if an individual is a male or a female. This work was done in 1905. The experiments done to determine this used a range of insects, she identified the Y chromosome in the mealworm Tenebrio. She deduced the chromosomal basis of sex depended on the presence or absence of the Y chromosome. She did not start her research until her thirties and completed her PhD in 1903. She successfully expanded the fields of embryology and cytogenetics. She died on May 4, 1912 of breast cancer, at Johns Hopkins Hospital, before she was able to fully take up a new faculty position.
Stevens is a somewhat controversial character. Following her death, Thomas Hunt Morgan wrote an extensive yet dismissive obituary for the journal Science, implying that she was more of a technician than a scientist. This later assessment belies his earlier statement in a letter of recommendation: "Of the graduate students that I have had during the last twelve years I have had no one that was as capable and independent in research as Miss Stevens...".
Stevens was the first to recognize that females have two large sex chromosomes. Wilson did not see this because he only performed tests on the testis because eggs are too fatty for the old staining procedures. Wilson even reissued his original paper and thanked Nettie Stevens for this finding. This finding is what then allowed Wilson to combine his idea of idiochromosomes with her heterosomes. This shows that Stevens was very influential in this process. Most biology textbooks credit Morgan for mapping the first gene locations onto chromosomes of fruit flies Drosophila melanogaster, but what is often missed is that it was Stevens who brought the fruit fly into Morgan's lab in the first place.
Modern cytological work involves an intricacy of detail, the significance of which can be appreciated by the specialist alone; but Miss Stevens had a share in a discovery of importance, and her work will be remembered for this, when the minutiae of detailed investigations that she carried out have become incorporated in the general body of the subject.
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- "Nettie Maria Stevens - Turn-of-the-century Stanford alumna paved path for women in biology" (PDF). Stanford Historical Society. Archived from the original on 5 July 2010. Retrieved 18 August 2013.
- Gilgenkrantz, Simone (15 October 2008). "Nettie Maria Stevens (1861-1912)" (in français). Clérey-sur-Brénon, France: Médecine/Sciences. Archived from the original on 17 August 2013. Retrieved 18 August 2013.
- Morgan, T.H. (12 October 1912). "The Scientific Work of Miss N. M. Stevens". Science 36 (298): 468–470. doi:10.1126/science.36.928.468. JSTOR 1636618.
- Wessel, Gary M. (13 September 2011). "Y does it work this way?" (PDF). Molecular Reproduction and Development (Wiley) 78 (9). doi:10.1002/mrd.21390. Retrieved 20 August 2013.
- Brush, S G (Jun 1978). "Nettie M. Stevens and the discovery of sex determination by chromosomes". Isis; an international review devoted to the history of science and its cultural influences (United States) 69 (247): 163–72. doi:10.1086/352001. ISSN 0021-1753. PMID 389882.
- Ogilvie, M B; Choquette C J (Aug 1981). "Nettie Maria Stevens (1861-1912): her life and contributions to cytogenetics". Proceedings of the American Philosophical Society (United States) 125 (4): 292–311. ISSN 0003-049X. PMID 11620765.
- Gilgenkrantz, Simone (Oct 2008). "Nettie Maria Stevens (1861-1912)". Med Sci (Paris) (France) 24 (10): 874–8. doi:10.1051/medsci/20082410874. ISSN 0767-0974. PMID 18950586.
- Biography of Nettie Stevens
- Cleveland, Hillary. "Women in Science". 3/6/09. Bryn Mawr College. Retrieved 20 June 2013.