The neuromatrix theory of pain states that the perception of painful stimuli does not result from the brain's passive registration of tissue trauma, but from its active generation of subjective experiences through a network of neurons known as the neuromatrix. The theory was proposed by Ronald Melzack in 1990.
- Chapman, C. Richard. "Neuromatrix theory". Pain Forum 5 (2): 139–142. doi:10.1016/S1082-3174(96)80051-1.
- Melzack, Ronald. "Phantom limbs and the concept of a neuromatrix". Trends in Neurosciences 13 (3): 88–92. doi:10.1016/0166-2236(90)90179-E.
- Fuchs, Perry N.; Peng, Yuan Bo; Boyette-Davis, Jessica A.; Uhelski, Megan L. (5 May 2014). "The anterior cingulate cortex and pain processing". Frontiers in Integrative Neuroscience 8. doi:10.3389/fnint.2014.00035.
A number of different lines of evidence indicate that the ACC is a critical brain region that is part of the neuromatrix involved in pain processing