Neuropeptide Y receptor Y2

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Neuropeptide Y receptor Y2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NPY2R ; NPY2-R
External IDs OMIM162642 MGI108418 HomoloGene701 IUPHAR: Y2 ChEMBL: 4018 GeneCards: NPY2R Gene
RNA expression pattern
PBB GE NPY2R 210730 s at tn.png
PBB GE NPY2R 210729 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4887 18167
Ensembl ENSG00000185149 ENSMUSG00000028004
UniProt P49146 P97295
RefSeq (mRNA) NM_000910 NM_001205099
RefSeq (protein) NP_000901 NP_001192028
Location (UCSC) Chr 4:
156.13 – 156.14 Mb
Chr 3:
82.54 – 82.55 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 2 (Y2R) is a protein that in humans is encoded by the NPY2R gene.[1][2]


Selective Ligands[edit]

Agonists[edit]

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • Neuropeptide Y fragment 13-36 (NPY2 selective agonist)
  • 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
  • Peptide YY
  • Peptide YY 3-36 fragment[3]

Antagonists[edit]

  • BIIE-0246 (CAS# 246146-55-4)
  • JNJ 5207787 (CAS# 683746-68-1)
  • SF 11 (CAS# 443292-81-7)

See also[edit]

References[edit]

  1. ^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Nov 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". J Biol Chem 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383. 
  2. ^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2". 
  3. ^ Murphy KG, Dhillo WS, Bloom SR (December 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190. 

External links[edit]

Further reading[edit]