Neuropeptide Y receptor Y2

Neuropeptide Y receptor Y2
Identifiers
Symbols	NPY2R;
External IDs	OMIM: 162642 MGI: 108418 HomoloGene: 701 IUPHAR: Y2 GeneCards: NPY2R Gene
Gene Ontology Molecular function • peptide YY receptor activity • receptor activity • G-protein coupled receptor activity • neuropeptide Y receptor activity • calcium channel regulator activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • outflow tract morphogenesis • cardiac left ventricle morphogenesis • inhibition of adenylate cyclase activity by G-protein signaling pathway • locomotory behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4887	18167
Ensembl	ENSG00000185149	ENSMUSG00000028004
UniProt	P49146	Q8BWV1
RefSeq (mRNA)	NM_000910	NM_008731
RefSeq (protein)	NP_000901	NP_032757
Location (UCSC)	Chr 4: 156.13 – 156.14 Mb	Chr 3: 82.34 – 82.35 Mb
PubMed search	[1]	[2]

Neuropeptide Y receptor type 2 is a protein that in humans is encoded by the NPY2R gene.

Selective Ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
• Peptide YY
• Peptide YY 3-36 fragment

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2368. 

Further reading

• Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=402104. 
• Gerald C, Walker MW, Vaysse PJ, et al. (1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". J. Biol. Chem. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910. 
• Lynch JW, Lemos VS, Bucher B, et al. (1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". J. Biol. Chem. 269 (11): 8226–33. PMID 8132547. 
• Gehlert DR, Beavers LS, Johnson D, et al. (1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Mol. Pharmacol. 49 (2): 224–8. PMID 8632753. 
• Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39335. 
• Ammar DA, Eadie DM, Wong DJ, et al. (1997). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716. 
• Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
• Caberlotto L, Fuxe K, Rimland JM, et al. (1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. 
• Goumain M, Voisin T, Lorinet AM, et al. (2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Mol. Pharmacol. 60 (1): 124–34. PMID 11408607. 
• Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573267. 
• Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hyland NP, Sjöberg F, Tough IR, et al. (2004). "Functional consequences of neuropeptide Y Y2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". Br. J. Pharmacol. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573894. 
• Hung CC, Pirie F, Luan J, et al. (2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.