Neuropilin 1

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Neuropilin 1
Protein NRP1 PDB 1kex.png
PDB rendering based on 1kex.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NRP1 ; BDCA4; CD304; NP1; NRP; VEGF165R
External IDs OMIM602069 MGI106206 HomoloGene2876 ChEMBL: 5174 GeneCards: NRP1 Gene
RNA expression pattern
PBB GE NRP1 212298 at tn.png
PBB GE NRP1 210510 s at tn.png
PBB GE NRP1 210615 at tn.png
More reference expression data
Species Human Mouse
Entrez 8829 18186
Ensembl ENSG00000099250 ENSMUSG00000025810
UniProt O14786 P97333
RefSeq (mRNA) NM_001024628 NM_008737
RefSeq (protein) NP_001019799 NP_032763
Location (UCSC) Chr 10:
33.47 – 33.63 Mb
Chr 8:
128.36 – 128.51 Mb
PubMed search [1] [2]

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene.[1][2][3] This is one of two human neuropilins.

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM][3]


Neuropilin 1 has been shown to interact with Vascular endothelial growth factor A.[1][4]


  1. ^ a b Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (April 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250. 
  2. ^ Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (November 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. 
  3. ^ a b "Entrez Gene: NRP1 neuropilin 1". 
  4. ^ Mamluk, Roni; Gechtman Ze'ev; Kutcher Matthew E; Gasiunas Nijole; Gallagher John; Klagsbrun Michael (Jul 2002). "Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol. Chem. (United States) 277 (27): 24818–25. doi:10.1074/jbc.M200730200. ISSN 0021-9258. PMID 11986311. 

Further reading[edit]