SERPINI1

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Serpin peptidase inhibitor, clade I (neuroserpin), member 1
Protein SERPINI1 PDB 1jjo.png
PDB rendering based on 1jjo.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SERPINI1 ; PI12; neuroserpin
External IDs OMIM602445 MGI1194506 HomoloGene21045 GeneCards: SERPINI1 Gene
RNA expression pattern
PBB GE SERPINI1 205352 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5274 20713
Ensembl ENSG00000163536 ENSMUSG00000027834
UniProt Q99574 O35684
RefSeq (mRNA) NM_001122752 NM_009250
RefSeq (protein) NP_001116224 NP_033276
Location (UCSC) Chr 3:
167.45 – 167.54 Mb
Chr 3:
75.56 – 75.64 Mb
PubMed search [1] [2]

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[1]

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][1]

Interactions[edit]

SERPINI1 has been shown to interact with Tissue plasminogen activator.[2]

References[edit]

  1. ^ a b "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1". 
  2. ^ Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. (England) 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.025