Neurothekeoma is a benign cutaneous tumor first described by Gallager and Helwig, who proposed the term in order to reflect the presumed origin of the lesion from nerve sheath. Microscopically, the lesions described closely resembled the tumor, “nerve sheath myxoma,” an entity first described by Harkin and Reed. The latter had, through the years, been variously described as “Bizarre cutaneous neurofibroma,” “Myxoma of nerve sheath,” and “Pacinian neurofibroma.”
Clinically, neurothekeomas present as a solitary nodule of the skin  The most common sites of occurrence are the head and neck and the extremities. The lesions range in size from about 0.5 cm. to more than 3 cm. The average patient age is about 25 years, but neurothkeomas may occur at any age. Women are affected about more often; the male to female ratio is approximately 1:2.
Since the time of their first description, it has been reported that neurothekeomas are likely not of nerve sheath origin, as implied by the term. Consequently, neurothekeoma and nerve sheath myxoma are likely not related histogenetically, although they are similar in appearance and in behavior.
- List of cutaneous conditions
- List of histologic stains that aid in diagnosis of cutaneous conditions
- Myxoid tumor
- Gallager RL, Helwig EB. (December 1980). "Neurothekeoma-a benign cutaneous tumor of neural origin". American Journal of Clinical Pathology 74 (6): 759–764. PMID 7446487.
- Harkin, James C.; Richard J. Reed (1969), Tumors of the Peripheral Nervous System, in Armed Forces Institute of Pathology, ed: Atlas of Tumor Pathology, 2nd series, fascicle 3, Washington, D.C.: Armed Forces Institute of Pathology
- Pulitzer DR, Reed RJ. (October 1985). "Nerve-sheath myxoma (perineurial myxoma)". American Journal of Dermatopathology 7 (5): 407–421. PMID 4091218.
- Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen. (July 2007). "Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information". American Journal of Surgical Pathology 31 (7): 1103–1114. doi:10.1097/pas.0b013e31802d96af. PMID 17592278.
- Reed, Richard J.; Pulitzer, Donald R. (2008), Tumors of Neural Tissue, Chapter 35 in Lever’s Histopathology of the Skin, Ninth edition, Elder, D, et al, eds, Philadelphia: Lippincott Raven, ISBN 0781773636
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