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Neutersol is a brand name for Zinc gluconate (neutralized by Arginine), a compound used to produce infertility in the male dog by chemical disruption of the testicle, intended as an alternative to surgical neutering. Neutersol was developed by Pet Healthcare International, Inc. Neutersol was approved by the U.S. Food and Drug Administration (FDA) for small puppies in 2003.[1] In 2005 however, Pet Healthcare International severed its ties with its manufacturing partner Addison Biologicals, and production of the drug stopped.[2] Neutersol had been expected to be reintroduced into the market by early 2009, but that plan was stalled. Ark Sciences, Inc. has acquired the intellectual property rights to this method of sterilization, and reintroduced it to the U.S. market in February 2014 under the name Zeuterin, using the safer Esterilsol injection technique used internationally.[3]

Neutersol is contraindicated in cases of cryptorchidism, pre-existing scrotal dermatitis, testicular diseases and malformations, and drug hypersensitivity on Neutersol components.