Neutrophil cytosolic factor 1

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Neutrophil cytosolic factor 1
Protein NCF1 PDB 1gd5.png
PDB rendering based on 1gd5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NCF1 ; NCF1A; NOXO2; SH3PXD1A; p47phox
External IDs OMIM608512 MGI97283 HomoloGene30964 ChEMBL: 1613743 GeneCards: NCF1 Gene
Species Human Mouse
Entrez 653361 17969
Ensembl ENSG00000158517 ENSMUSG00000015950
UniProt P14598 Q09014
RefSeq (mRNA) NM_000265 NM_001286037
RefSeq (protein) NP_000256 NP_001272966
Location (UCSC) Chr 7:
74.19 – 74.2 Mb
Chr 5:
134.22 – 134.23 Mb
PubMed search [1] [2]

Neutrophil cytosol factor 1 is a protein that in humans is encoded by the NCF1 gene.

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.[1] p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated


Neutrophil cytosolic factor 1 has been shown to interact with Moesin,[2] RELA[3] and Neutrophil cytosolic factor 4.[4][5][6]


  1. ^ "Entrez Gene: NCF1 neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)". 
  2. ^ Wientjes, F B; Reeves E P; Soskic V; Furthmayr H; Segal A W (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain". Biochem. Biophys. Res. Commun. (United States) 289 (2): 382–8. doi:10.1006/bbrc.2001.5982. ISSN 0006-291X. PMID 11716484. 
  3. ^ Gu, Ying; Xu You Cheng; Wu Ru Feng; Nwariaku Fiemu E; Souza Rhonda F; Flores Sonia C; Terada Lance S (May 2003). "p47phox participates in activation of RelA in endothelial cells". J. Biol. Chem. (United States) 278 (19): 17210–7. doi:10.1074/jbc.M210314200. ISSN 0021-9258. PMID 12618429. 
  4. ^ Lapouge, Karine; Smith Susan J M; Groemping Yvonne; Rittinger Katrin (Mar 2002). "Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox". J. Biol. Chem. (United States) 277 (12): 10121–8. doi:10.1074/jbc.M112065200. ISSN 0021-9258. PMID 11796733. 
  5. ^ Grizot, S; Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu J P, Fuchs A, Vignais P V, Timmins P A, Dagher M C, Pebay-Peyroula E (Mar 2001). "Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox". Biochemistry (United States) 40 (10): 3127–33. doi:10.1021/bi0028439. ISSN 0006-2960. PMID 11258927. 
  6. ^ Sathyamoorthy, M; de Mendez I; Adams A G; Leto T L (Apr 1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. (UNITED STATES) 272 (14): 9141–6. doi:10.1074/jbc.272.14.9141. ISSN 0021-9258. PMID 9083043. 

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