Newport Pagnell Services were the second service station to be opened in the UK, but as the Watford Gap services were originally only for trucks, Newport Pagnell was the first to open for all traffic. It opened in 1960.
The service station is one of fourteen for which large murals were commissioned from artist David Fisher in the 1990s, designed to reflect the local area and history.
On 3 September 2007, a National Express coach from Birmingham to Luton airport and Stansted airport (making an unscheduled stop) failed to make a turn on the approach road and overturned. A number of people including the driver were seriously injured. The driver was subsequently convicted of drink driving and dangerous driving.