Niacin receptor 2

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Hydroxycarboxylic acid receptor 3
Symbols HCAR3 ; GPR109B; HCA3; HM74; PUMAG; Puma-g
External IDs OMIM606039 HomoloGene130547 IUPHAR: 313 ChEMBL: 4421 GeneCards: HCAR3 Gene
Species Human Mouse
Entrez 8843 n/a
Ensembl ENSG00000255398 n/a
UniProt P49019 n/a
RefSeq (mRNA) NM_006018 n/a
RefSeq (protein) NP_006009 n/a
Location (UCSC) Chr 12:
123.2 – 123.2 Mb
PubMed search [1] n/a

Niacin receptor 2, also known as NIACR2 or GPR109B, is a protein which in humans is encoded by the NIACR2 gene.[1][2]


GPR109B is a low affinity receptor for nicotinic acid (niacin)[3] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).

GPR109B is a Gi /Go protein-coupled receptor with low affinity for nicotinic acid.[3]


  1. ^ "Entrez Gene: GPR109B G protein-coupled receptor 109B". 
  2. ^ Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  3. ^ a b Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 

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