Nicardipine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Nicardipine
Nicardipine.svg
Systematic (IUPAC) name
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names Cardene
AHFS/Drugs.com monograph
MedlinePlus a695032
Legal status
  • Prescription only
Routes Oral, intravenous
Pharmacokinetic data
Protein binding >95%
Half-life 8.6 hours
Identifiers
CAS number 55985-32-5 YesY
ATC code C08CA04
PubChem CID 4474
IUPHAR ligand 2559
DrugBank DB00622
ChemSpider 4319 YesY
UNII CZ5312222S YesY
KEGG D08270 YesY
ChEMBL CHEMBL1484 YesY
Chemical data
Formula C26H29N3O6 
Mol. mass 479.525 g/mol
Physical data
Melt. point 136-138 °C (-80 °F)
 YesY (what is this?)  (verify)

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers.

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It is available in oral and intravenous formulations. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Furthermore, nicardipine does not intrinsically decrease myocardial contractility and may be useful in the management of congestive heart failure. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for both Cardene and Cardene SR expired in October 1995.[1]

It has been used in percutaneous coronary intervention.[2]


References[edit]

  1. ^ Nicardipine at Medline PLus
  2. ^ Huang RI, Patel P, Walinsky P, et al. (November 2006). "Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention". Catheter Cardiovasc Interv 68 (5): 671–6. doi:10.1002/ccd.20885. PMID 17034064.