Nicholas Joseph Clayton (November 1, 1840 in Cloyne, County Cork - December 9, 1916) was a prominent Victorian era architect in Galveston, Texas. Clayton constructed many grand religious and public buildings in Galveston including the First Presbyterian Church (Galveston, Texas). He is also credited as the architect of Sacred Heart Catholic Church (Tampa, Florida). He also designed an addition to St. Mary Cathedral in Galveston.
- Barrie Scardino and Drexel Turner (2000). Clayton's Galveston : the architecture of Nicholas J. Clayton and his contemporaries. College Station: Texas A&M University Press. ISBN 0-89096-881-0.