Nicholas Lydon

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Nicholas Lydon
Nicholas Lydon.jpg
Born (1957-02-27) February 27, 1957 (age 57)[citation needed]
Institutions
Alma mater
Thesis Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum (1982)
Known for
  • Gleevec
  • AnaptysBio
  • BluePrint Medicines
Notable awards
Website
royalsociety.org/people/nicholas-lydon

Nicholas B. Lydon FRS (born 27 February 1957) is a British scientist and entrepreneur.[1] In 2009 he was awarded the Lasker Clinical Award and in 2012 the Japan Prize for the development of Gleevec, a selective BCR-ABL inhibitor for the treatment of chronic myeloid leukemia (CML); converting a fatal cancer into a manageable chronic condition.[2][3][4][5] [6][7]

Education[edit]

Lydon was educated at Strathallan School near Perth, Scotland.[8] He earned a Bachelor of Science degree in biochemistry from the University of Leeds, England in 1978 and received his Ph.D in biochemistry from the University of Dundee, Scotland in 1982.[9][8]

Career[edit]

In 1982 Lydon accepted a position with Schering-Plough based in France as Charge de Recherche.[3] Three years later he moved to Switzerland to work with Ciba-Geigy Pharmaceuticals, with whom he developed Gleevec.[8] In 1997 he established Kinetex Pharmaceuticals in Boston which was acquired by Amgen in 2000, with whom he worked until 2002.[8] Thereafter, he established several companies that continue to develop drugs to treat various conditions.[8]

Honours and awards[edit]

Lydon's nomination for the Royal Society reads:

Nick Lydon played a decisive role in the development of Gleevec (Imatinib), a drug that has saved the lives of thousands of patients with chronic myelogenous leukaemia (CML) and gastrointestinal stromal tumours (GIST). Gleevec revolutionized the field of cancer drug discovery by changing rapidly fatal diseases into easily treatable conditions, and showed that, by targeting an oncogene that is the molecular cause of a specific cancer, the defective cancer cells can be killed without any major side effects on normal cells. The remarkable efficacy of Gleevec profoundly changed the perception of protein kinases as therapeutic targets. From being considered to be virtually “undruggable” in 1994, they have become the pharmaceutical industry's most popular class of drug target today, accounting for over 50% of cancer drug discovery R&D. The international prizes that Nick Lydon has received include, most recently, the Lasker-DeBakey Clinical Medical Research Award from The Lasker Foundation.[10]

References[edit]

  1. ^ "Nicholas Lydon". ScienceHeroes.com. 2010. Retrieved 13 February 2013. 
  2. ^ "Lasker - DeBakey Clinical Medical Research Award: Award Description". Lasker Foundation. Retrieved 16 August 2010. 
  3. ^ a b c d e f g h "Laureates of the Japan Prize". The Japan Prize Foundation. 2012. Retrieved 13 February 2013. 
  4. ^ Druker, B. J.; Talpaz, M.; Resta, D. J.; Peng, B.; Buchdunger, E.; Ford, J. M.; Lydon, N. B.; Kantarjian, H.; Capdeville, R.; Ohno-Jones, S.; Sawyers, C. L. (2001). "Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia". New England Journal of Medicine 344 (14): 1031–1037. doi:10.1056/NEJM200104053441401. PMID 11287972. 
  5. ^ List of publications from Microsoft Academic Search
  6. ^ Druker, B. J.; Tamura, S.; Buchdunger, E.; Ohno, S.; Segal, G. M.; Fanning, S.; Zimmermann, J.; Lydon, N. B. (1996). "Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells". Nature medicine 2 (5): 561–566. doi:10.1038/nm0596-561. PMID 8616716. 
  7. ^ Buchdunger, E.; Cioffi, C. L.; Law, N.; Stover, D.; Ohno-Jones, S.; Druker, B. J.; Lydon, N. B. (2000). "Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors". The Journal of pharmacology and experimental therapeutics 295 (1): 139–145. PMID 10991971. 
  8. ^ a b c d e "Dr Nicholas Lydon". University of Dundee. 2011. Retrieved 13 February 2013. 
  9. ^ Lydon, Nicholas B. (1982). Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum (PhD thesis). University of Dundee. (subscription required)
  10. ^ a b "Dr Nicholas Lydon". Royal Society. 2013. Retrieved 29 May 2013. 
  11. ^ "GlaxoSmithKline prize". Royal Society. Retrieved 12 September 2013.