Little is known about the life of Nicolaus. He is probably the same physician who is mentioned by George Acropolites as being eminent in his profession, but very ignorant of natural philosophy. He was at the court of John III Doukas Vatatzes at Nicaea, when the eclipse of the sun took place October 6 1241, that shortly preceded the death of the empress Irene. Here he was held in great esteem by the emperor, and attained the dignity of actuarius. All this agrees very well with the scattered notices of his date and his personal history that we find in his own work. He mentions Mesue the Younger, who died 1015; "Michael Angelus regalis," who is probably Michael VIII Palaiologos who began to reign 1259; "Papa Nicolaus," who seems to be Pope Nicholas III, who began to reign 1277; and "Dominus Joannes," and "Magister Johannes," who is probably Joannes Actuarius, who lived in the 13th century. He mentions his having visited or lived at Nicaea, and also Alexandria, whence he is sometimes called Nicolaus Alexandrinus.
Nicolaus compiled and revised Ancient Greek scripts including, but not limited to Galen, as well as writing his own compendium on medical science, named Dynameron. It consists of 48 sections, containing more than 2500 medical formulae, arranged according to their form and object. It is chiefly compiled from former writers, and contains many superstitious remedies. It remained the principal pharmaceutical code of the Parisian medical faculty until 1651.
- George Acropolites, Hist. Byzant. c. 39, p. 34
- Nicolaus Myrepsus, xxxii. 117, p. 706
- Nicolaus Myrepsus, i. 295, p. 420
- Nicolaus Myrepsus, ii. 9, p. 469
- Nicolaus Myrepsus, x. 103, p. 575
- Nicolaus Myrepsus, xxxii. 99, p. 703
- Nicolaus Myrepsus, xxiv. 12, p. 657
- Nicolaus Myrepsus, i. 241, xvii. 17, pp. 412, 612
- Deno John Geanakoplos, (1966), Byzantine East and Latin West: Two Worlds of Christendom in Middle Ages and Renaissance, page 31. Barnes & Noble
- This article incorporates text from a publication now in the public domain: Smith, William, ed. (1870). "article name needed". Dictionary of Greek and Roman Biography and Mythology.