The block replaced CBS Kidshow, a block primarily composed of imported Canadian programming, that ran from 1997 to 2000. For the first two years, Nick Jr. on CBS aired programming exclusively from Nick Jr., including interstitials from Face, Nick Jr.'s mascot. On September 14, 2002, Nick Jr. on CBS was rebranded as Nick on CBS, expanding its lineup to include Nickelodeon shows not featured on Nick Jr.'s lineup. The Nickelodeon shows were removed in 2005 in favor for a return to an exclusively-Nick Jr. block. The block's continuity was provided by segments featuring Piper O'Possum.
As with most Saturday morning children's blocks, all programming was E/I compliant, which was part of the reason why some of Nickelodeon's most popular programs were not aired on CBS. For example, SpongeBob SquarePants (at the time Nick's most popular show) only aired on CBS as one-time special presentations and not as a regular part of the block.Rugrats also aired as one-time special presentations, before airing as part of the block.
^CBS aired the SpongeBob episodes, "Christmas Who?", on Christmas 2002, "The Sponge Who Could Fly" on Earth Day 2003, "Friend or Foe" on June 15, 2007 and "WhoBob WhatPants" on Earth Day 2009, and "It's a SpongeBob Christmas!" on November 23, 2012.