Niclosamide

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Niclosamide
Niclosamide.svg
Systematic (IUPAC) name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status ?
Identifiers
CAS number 50-65-7 N
ATC code P02DA01 QP52AG03
PubChem CID 4477
DrugBank DB06803
ChemSpider 4322 YesY
UNII 8KK8CQ2K8G YesY
KEGG D00436 YesY
ChEMBL CHEMBL1448 YesY
Chemical data
Formula C13H8Cl2N2O4 
Mol. mass 327.119 g/mol
 N (what is this?)  (verify)

Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide. It is stressed that while antihelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against other worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. Niclosamide molecules are lethal to tapeworms upon contact.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]

Side effects[edit]

The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis. Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.

Mechanism of action[edit]

According to an article in Nature,[2] niclosamide uncouples oxidative phosphorylation in the tapeworm.

References[edit]

  1. ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014. 
  2. ^ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature 221 (5185): 1016–8. doi:10.1038/2211016a0. PMID 4180173. 

External Links[edit]