Nicotinamidase

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nicotinamidase
Identifiers
EC number 3.5.1.19
CAS number 9033-32-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nicotinamidase (EC 3.5.1.19) is an enzyme that catalyzes the chemical reaction

nicotinamide + H2O \rightleftharpoons nicotinate + NH3

Thus, the two substrates of this enzyme are nicotinamide and H2O, whereas its two products are nicotinate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide amidohydrolase. Other names in common use include nicotinamide deaminase, nicotinamide amidase, and YNDase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1ILW, 1IM5, and 2H0R.

References[edit]

  • Petrack B, Greengard P, Craston A and Sheppy F (1965). "Nicotinamide deamidase from mammalian liver". J. Biol. Chem. 240: 1725–1730. PMID 14285515. 
  • Sarma DSR, Rajalakshmi S and Sarma S (1964). "Studies on the enzymes involved in nicotinamide adenine dinucleotide metabolism in Aspergillus niger". Biochim. Biophys. Acta 81: 311–322. doi:10.1016/0926-6569(64)90047-1.