Nicotine replacement therapy

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A nicotine patch is applied to the left arm
Nicotine pastilles used in therapy

Nicotine replacement therapy (commonly abbreviated to NRT) is a way to give nicotine to the body by means other than tobacco. It is used to decrease withdrawal symptoms triggered by stopping smoking or chewing tobacco cessation.[1]

Nicotine replacement therapy reduces cravings caused by nicotine addiction in smokers and chewers, helping them quit tobacco use—and thus avoid the harmful effects of smoking and chewing tobacco. The habit of smoking and chewing is both a learned behavior and a physical addiction to nicotine, therefore the use of both nicotine replacement products and counseling may help those trying to quit.[2] The use of nicotine replacement therapy increases the success of initially quitting smoking by 50 to 70%.[1]

Nicotine replacement products are on the WHO Model List of Essential Medicines, a list of the most important medication needed in a basic health system.[3] The United States Public Health Service lists 7 medical agents for the stopping of tobacco, which include 5 nicotine replacement treatments (nicotine patches, gum, lozenges, inhalers, and nasal sprays) and 2 oral medications (bupropion and varenicline).[4] Other NRT options are available, including nicotine mouth sprays and sublingual tablets.[4]

Medical uses[edit]

Nicotine replacement therapy, in the form of gum, patches, nasal spray, inhaler and lozenges all improve the ability of people trying to quit tobacco products.[1] Studies have shown that nicotine replacement therapy is equally as effective as medications such as bupropion, in helping people quit smoking for at least 6 months.[5] Studies have also shown that each form of nicotine replacement therapy, including nicotine gum, patches, nasal spray, inhalers, and lozenges have similar success rates in terms of helping people stop smoking. However, the likelihood that someone will stick to a certain treatment varied, with compliance being the highest with nicotine patches, followed by nicotine gum, inhalers, and nasal sprays.[6] It is important to note that using a few different nicotine replacement methods in combination may improve one's success rates in stopping tobacco use.[5] Additionally, using nicotine replacement with counseling has been proven to improve tobacco abstinence rates.[2]

Nicotine replacement products are most beneficial for heavy smokers who smoke more than 15 cigarettes per day. There are not enough studies to show that NRT helps those who smoke fewer than 10 cigarettes per day.[7]

Side effects[edit]

While there is no evidence that NRT can increase the risk of heart attacks,[1] individuals with pre-existing cardiovascular conditions or recent heart attacks should consult a physician before initiating NRT.[8]

If you are under 18 years of age, you should consult your physician before starting NRT.[8]

Nicotine exposure during pregnancy can result in attention deficit hyperactivity disorder (ADHD) and learning disabilities in the child. It also puts the child at risk for nicotine addiction in the future.[9] Thus, pregnant women and those who are breastfeeding should also consult a physician before initiating NRT.[8] The gum, lozenge, and nasal spray are pregnancy category C. The transdermal patch is pregnancy category D. The transdermal patch is considered less safe for the fetus because it delivers continuous nicotine exposure as opposed to the gum or lozenge, which delivers intermittent and thus lower nicotine exposure.[9][10]


Nicotine replacement products vary in the time it takes for the nicotine to enter the body and the total time nicotine stays in the body.[2]

Nicotine patches are applied to the skin and continuously administer a stable dose of nicotine slowly over 16–24 hours.[2][10] Nicotine gum, nicotine sprays, nicotine sublingual tablets, and nicotine lozenges administer nicotine orally with quicker nicotine uptake into the body, but lasting a shorter amount of time. Nicotine inhalers are metered-dose inhalers that administer nicotine through the lungs and mucous membranes of the throat quickly, but lasting a short amount of time. For example, blood nicotine levels are the highest 5–10 minutes after using the nicotine nasal spray, 20 minutes after using a nicotine inhaler or chewing nicotine gum, and 2–4 hours after using a nicotine patch.[2][11]


Another concern relates to the fact that people may become addicted to the NRT product and turn back to tobacco products to save money. Typically, the cost of NRT lasting seven days is up to £20 over the counter, whether spray, gum or inhaler, as against £7 to £8 for twenty tax paid cigarettes, or £3 for tax paid rolling tobacco. The cost of cigarettes or tobacco over the same period varies depending on the smoker, while the cost of NRT remains static regardless of the level of nicotine it contains. This leads to the relative cost of NRT versus cigarettes or tobacco being dependent on how much the individual smokes. The British NHS provides help in the form of prescriptions, reducing the cost to £7.40 per script or for free in Scotland, and if several products are included on one script then the price will drop well below that of actual cigarettes or may even cost nothing at all.[citation needed]

Exempted populations[edit]

Evaluation of NRT in real-world studies produces more modest outcomes than efficacy studies conducted by the industry-funded trials. The National Health Service (NHS) in England has a smoking cessation service based on pharmacotherapy in combination with counseling support. An Action on Smoking and Health (ASH) report claims that the average cost per life year gained for every smoker successfully treated by these services is less than £1,000 (below the NICE guidelines of £20,000 per QALY (quality-adjusted life year). However, the investment in NHS stop smoking services is relatively low. A comparison with treatment costs for illicit drug users shows that £585 million is committed for 350,000 problem drug users compared to £56 million for 9 million users of tobacco. This is £6.20 for each smoker, compared to £1,670 per illegal drug user (Action on Smoking & Health, 2008).

Disappointingly, the claims for high efficacy and cost-effectiveness of NRT have not been substantiated in real-world effectiveness studies.[12][13][14] Pierce and Gilpin (2002) stated their conclusion as follows: “Since becoming available over the counter, NRT appears no longer effective in increasing long-term successful cessation” (p. 1260).[14] Efficacy studies, which are conducted using randomized controlled trials, do not transfer very well to real-world effectiveness. Bauld, Bell, McCullough, Richardson and Greaves (2009) reviewed 20 studies the effectiveness of intensive NHS treatments for smoking cessation published between 1990 and 2007.[15] Quit rates showed a dramatic decrease between 4-weeks and one year. A quit rate of 53% at four weeks fell to only 15% at 1 year. Younger smokers, females, pregnant smokers and more deprived smokers had lower quit rates than other groups.

Non-prescription nicotine[edit]

Snus and nasal snuff also allow for nicotine administration outside of tobacco smoking,[16] but do cause negative health effects.

Electronic cigarettes, also known as vapourisers or electronic nicotine delivery systems (ENDS), are often, although not always, designed to look and feel like cigarettes. They have been marketed as less harmful alternatives to cigarettes,[17] but they are not approved as NRTs in any jurisdiction, so evidence of safety or efficacy is weak. Some electronic cigarettes have coarsely adjustable nicotine levels. Negative health affects and efficacy are still under investigation and medical organisations do not recommend e-cigarettes.

The U.S. Food and Drug Administration (FDA) has a list of additional tobacco products they are seeking to regulate, including electronic cigarettes.[18] The evidence suggests that the FDA accepted products such as a nicotine inhaler may be a safer way to give nicotine than e-cigarettes.[19]

Global health[edit]

Nicotine replacement products are on the WHO Model List of Essential Medicines, a list of the most important medication needed in a basic health system.[3]

Trade names[edit]

Trade names include Nicotex, Nicorette, Nicoderm, Nicogum, Nicotinell, Thrive and Commit Lozenge.

See also[edit]


  1. ^ a b c d Stead, LF; Perera, R; Bullen, C; Mant, D; Hartmann-Boyce, J; Cahill, K; Lancaster, T (Nov 14, 2012). Stead, Lindsay F, ed. "Nicotine replacement therapy for smoking cessation". The Cochrane database of systematic reviews 11: CD000146. doi:10.1002/14651858.CD000146.pub4. PMID 23152200. 
  2. ^ a b c d e Rigotti, NA. "Clinical practice. Treatment of tobacco use and dependence.". The New England journal of medicine 346 (7): 506–12. PMID 11844853. 
  3. ^ a b "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014. 
  4. ^ a b Fiore MC, Jaen CR, Baker TB et al. "Treating tobacco use and dependence: 2008 update.". US Department of Health and Human Services. 
  5. ^ a b Cahill, K; Stevens, S; Perera, R; Lancaster, T. "Pharmacological interventions for smoking cessation: an overview and network meta-analysis.". The Cochrane database of systematic reviews 5: CD009329. PMID 23728690. 
  6. ^ Hajek, Peter; West, Robert; Foulds, Jonathan; Nilsson, Fredrik; Burrows, Sylvia; Meadow, Anna. "Randomized Comparative Trial of Nicotine Polacrilex, a Transdermal Patch, Nasal Spray, and an Inhaler". Archives of Internal Medicine 159 (17): 2033. doi:10.1001/archinte.159.17.2033. 
  7. ^ "Nicotine replacement therapy". MedlinePlus. U.S. National Library of Medicine. Retrieved 28 October 2014. 
  8. ^ a b c "FDA 101: Smoking Cessation Products". U.S. Food and Drug Administration. Retrieved 28 October 2014. 
  9. ^ a b Bruin, Jennifer; Gerstein, Hertzel; Holloway, Alison (2 April 2010). "Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review". Toxicological Sciences 116 (2): 364–374. doi:10.1093/toxsci/kfq103. 
  10. ^ a b Oncken, MD, MPH, Cheryl; Dornelas, Ph.D., Ellen; Kranzler MD, Henry (28 October 2014). "Nicotine Gum for Pregnant Smokers" 112 (4). pp. 859–867. doi:10.1097/AOG.0b013e318187e1ec. Retrieved 28 October 2014. 
  11. ^ Package insert monograph with Nicorette® inhaler
  12. ^ Doran et al. (2006), pp. 758–766
  13. ^ Ferguson et al. (2006) in Addiction, pp. 59–69
  14. ^ a b Pierce & Gilpin (2002) in JAMA v. 288 pp. 1260–1264
  15. ^ Bauld et al. (2010) in J Public Health (Oxf), v. 32, pp. 71–82
  16. ^ Phillips, CV; Heavner, KK (2009). "Smokeless tobacco: The epidemiology and politics of harm". Biomarkers 14 (Suppl 1): 79–84. doi:10.1080/13547500902965476. PMID 19604065. 
  17. ^ "The use of electronic cigarette". Retrieved 10 November 2014. 
  18. ^
  19. ^ Drummond, MB; Upson, D (February 2014). "Electronic cigarettes. Potential harms and benefits.". Annals of the American Thoracic Society 11 (2): 236–42. doi:10.1513/annalsats.201311-391fr. PMID 24575993. 

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