Nieu-Bethesda (Dutch and Afrikaans for New Bethesda) is a village in the Eastern Cape at the foot of the Sneeuberge, approximately 50 kilometres (31 mi) from Graaff Reinet. It was founded in 1875 as a church town, like many other Karoo villages, and attained municipal status in 1886. The name is of biblical origin (John 5:2-4) and means "place of flowing water".
Originally established as congregation of the Dutch Reformed Church on the farm Uitkyk in 1875, it became a municipality about 1886. It now falls within the Camdeboo Local Municipality.