Niflumic acid

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Niflumic acid
Niflumic acid.png
Systematic (IUPAC) name
2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.
Legal status
?
Pharmacokinetic data
Half-life 2.5 hr[1]
Identifiers
CAS number 4394-00-7 YesY
ATC code M01AX02 M02AA17
PubChem CID 4488
IUPHAR ligand 2439
ChemSpider 4333 N
UNII 4U5MP5IUD8 N
KEGG D08275 YesY
ChEMBL CHEMBL63323 N
Chemical data
Formula C13H9F3N2O2 
Mol. mass 282.21797 g/mol
 N (what is this?)  (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.[2] It has also been reported to act on GABA-A[3] and NMDA channels[4] and to block T-type calcium channels.[5]

References[edit]

  1. ^ "Half life". Drug Bank. Retrieved 15 July 2011. 
  2. ^ Knauf, Philip A.; Mann, Nancy A (1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". J. Gen. Physiol. 83: 703–725. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917. 
  3. ^ Sinkkonen ST et al. (2003): Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug, Mol Pharmacol, p. 753-63. PMID 12920213
  4. ^ Lerma J., Martin d.R. (1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Mol. Pharmacol. 41 (2): 217–222. PMID 1371581. 
  5. ^ Balderas E et al. (2012): Niflumic acid blocks native and recombinant T-type channels, J Cell Physiol, p. 2542-55. PMID 21898399