Nikolsky's sign
From Wikipedia, the free encyclopedia
Nikolsky's sign is a clinical dermatological sign, named after the Russian physician Pyotr Nikolsky (1858–1940). The sign is positive when slight rubbing of the skin results in exfoliation of the outermost layer.[1][2][3][4]
Nikolsky's sign is almost always present in toxic epidermal necrolysis[5] and is associated with pemphigus vulgaris.[6] It is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent)
[edit] See also
[edit] References
- ^ Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. doi:10.1136/adc.79.3.290. PMC 1717681. PMID 9875032. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032.
- ^ "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm.
- ^ Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.
- ^ "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm.
- ^ Asz J, Asz D, Moushey R, Seigel J, Mallory SB, Foglia RP (December 2006). "Treatment of toxic epidermal necrolysis in a pediatric patient with a nanocrystalline silver dressing". J. Pediatr. Surg. 41 (12): e9–12. doi:10.1016/j.jpedsurg.2006.08.043. PMID 17161178.
- ^ Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.
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