Her first record production was titled Ninel Conde (2003), which contains the song "Callados", played a duet with singer José Manuel Figueroa. This material was nominated for a Latin Grammy in 2004 for "Mejor álbum grupero."
In 2004, Conde participated in the third edition of the reality show Big Brother VIP and was voted-off after 43 days of confinement. In October 2004, she began acting on Rebelde, produced by Pedro Damián. Her most remarkable role so far has been this one. Her role as Alma Rey in Rebelde (2004–2006) expanded her career to Chile, Romania, Colombia, Brasil, Peru, España, Croacia. This show was nominated for the awards TVyNovelas 2006 as "Best Lead Actress." Also involved in the film 7 mujeres, un homosexual y Carlos and Mujeres infieles 2.
In August 2009, Conde confirmed to appear in the MexicantelenovelaMar de amor as Coral (main-villain of the story), the telenovela was produced by Natalie Lartilleux. This show was nominated for "Best Actress antagonistic." In 2012 participates in the soap opera Porque el amor manda as Discua Paz De La Soledad.
From 1996 to 1998, she was married Mexican actor Ari Telch. She and Telch have one daughter together: Sofía Telch Conde (born May 7, 1997). Conde had a longstanding relationship with Mexican American singer José Manuel Figueroa, whom she dated from 2002 to 2006.
On December 7, 2007, Conde married her second husband, businessman Juan Zepeda. The couple separated in August 2013. It was reported in October 2013 that Conde was dating businessman Giovanni Medina. In April 2014, Conde announced that she and Medina were expecting a baby boy.