He taught at the University of Kansas before moving to Rome where he reported on the Catholic Church. He worked as the Italian correspondent for the New York Herald Tribune for eight years. Lo Bello mostly wrote travel articles and about the arts.
He wrote a tell-all book about the Vatican named The Vatican Papers, published in 1978 by New English Library, Sevenoaks, UK. The book, which delved into the financial side of the Catholic church, was a best-seller in 1968.