Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2gene.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
^Kuncewicz, T; Balakrishnan P; Snuggs M B; Kone B C (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. (United States) 281 (2): F326–36. ISSN0363-6127. PMID11457725.