Nitric oxide synthase 2 (inducible)

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Nitric oxide synthase 2, inducible
PDB 1nsi EBI.jpg
Rendering of 1NSI
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM163730 MGI97361 HomoloGene55473 ChEMBL: 4481 GeneCards: NOS2 Gene
EC number
RNA expression pattern
PBB GE NOS2A 210037 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4843 18126
Ensembl ENSG00000007171 ENSMUSG00000020826
UniProt P35228 P29477
RefSeq (mRNA) NM_000625 NM_010927
RefSeq (protein) NP_000616 NP_035057
Location (UCSC) Chr 17:
26.08 – 26.13 Mb
Chr 11:
78.92 – 78.96 Mb
PubMed search [1] [2]

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[1]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]


Nitric oxide synthase 2A has been shown to interact with Caveolin 1[3] and Rac2.[4]


  1. ^ Geller D, Lowenstein C, Shapiro R, Nussler A, Di Silvio M, Wang S et al. (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706. 
  2. ^ "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". 
  3. ^ Felley-Bosco E, Bender F, Courjault-Gautier F, Bron C, Quest A (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919. PMID 11114180. 
  4. ^ Kuncewicz T, Balakrishnan P, Snuggs M, Kone B (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.