Nitrotyrosine
| Nitrotyrosine[1] | |
|---|---|
 |
|
|
(2S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid |
|
|
Other names
3-Nitro-L-tyrosine; 3-Nitrotyrosine |
|
| Identifiers | |
| CAS number | 621-44-3 |
| PubChem | 65124 |
| ChemSpider | 58633  |
| DrugBank | DB03867 |
| ChEBI | CHEBI:44454 |
| Jmol-3D images | Image 1 |
|
|
|
|
| Properties | |
| Molecular formula | C9H10N2O5 |
| Molar mass | 226.19 g/mol |
| Appearance | Yellow to green crystalline solid |
| Melting point |
233-235 °C (dec.) |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It is detected in large number of pathological conditions[2][3] and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is found in numerous disease-affected tissues, such as the cornea in keratoconus.[4] Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetes[5]
[edit] References
- ^ 3-Nitro-L-tyrosine at Sigma-Aldrich
- ^ Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C (June 2006). "Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system". J. Surg. Res. 133 (2): 143–9. doi:10.1016/j.jss.2005.10.008. PMID 16360172. http://linkinghub.elsevier.com/retrieve/pii/S0022-4804(05)00544-5.
- ^ Pacher P, Beckman JS, Liaudet L (2007). "Nitric oxide and peroxynitrite in health and disease.". Physiol Rev. 87 (1): 315. doi:10.1152/physrev.00029.2006. PMC 2248324. PMID 17237348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2248324.
- ^ Buddi R, Lin B, Atilano SR, Zorapapel NC, Kenney MC, Brown DJ (March 2002). "Evidence of oxidative stress in human corneal diseases". J. Histochem. Cytochem. 50 (3): 341–51. doi:10.1177/002215540205000306. PMID 11850437. http://www.jhc.org/cgi/pmidlookup?view=long&pmid=11850437.
- ^ Pacher P, Obrosova IG, Mabley JG, Szabó C (2005). "Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies". Curr. Med. Chem. 12 (3): 267–75. PMC 2225483. PMID 15723618. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2225483.
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
