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Systematic (IUPAC) name
Clinical data
Legal status
  • Prescription only
Routes Oral
CAS number 16398-39-3
ATC code None
PubChem CID 27857
ChemSpider 25919
Chemical data
Formula C18H19N3O4 
Mol. mass 341.36 g/mol

Nitroxazepine (trade name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982.[1] It is also indicated for the treatment of nocturnal enuresis.[1] Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.[2][3][4]

See also[edit]


  1. ^ a b Progress in Medicinal Chemistry, Volume 22 (v. 22). Elsevier Science Publishing Company. 1985. p. 246. ISBN 0-444-80668-7. 
  2. ^ Progress in Medicinal Chemistry, Volume 23 (v. 23). Not Avail. 2000. p. 136. ISBN 0-444-80802-7. 
  3. ^ Ann Reports Medicinal Chem V11 (v. 11). Boston: Academic Press Inc. 1976. p. 4. ISBN 0-12-040511-3. 
  4. ^ Johnson O, Jones DW, Nagarajan K, Bhadbhade MM and Venkatesan K (1992). "X-ray crystal structure analysis of nitroxazepine: 10-(3-dimethylaminopropyl)-2-nitro-10,11-dihydrodibenz [b,f][l,4]oxazepin-11-one". Journal of Chemical Crystallography 22 (5).