Nizatidine
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| Systematic (IUPAC) name | |
| N-(2-[(2-[(dimethylamino)methyl]thiazol-4-yl)methylthio]ethyl)-N-methyl-2-nitroethene-1,1-diamine | |
| Clinical data | |
| Trade names | Axid |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a694030 |
| Licence data | US FDA:link |
| Pregnancy cat. | B3(AU) |
| Legal status | Prescription Only (S4) (AU) POM (UK) OTC (US) |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | >70% |
| Protein binding | 35% |
| Metabolism | Hepatic |
| Half-life | 1-2 hours |
| Excretion | Renal |
| Identifiers | |
| CAS number | 76963-41-2  |
| ATC code | A02BA04 |
| PubChem | CID 3033637 |
| DrugBank | APRD00706 |
| ChemSpider | 2298266 |
| UNII | P41PML4GHR |
| KEGG | D00440 |
| ChEMBL | CHEMBL653 |
| Chemical data | |
| Formula | C12H21N5O2S2 |
| Mol. mass | 331.46 g/mol |
| SMILES | eMolecules & PubChem |
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Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the brand names Tazac and Axid.
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[edit] Clinical use
Certain preparations of nizatidine are now available over the counter in various countries including the United States. Nizatidine has been used experimentally to control weight gain associated with some antipsychotic medication. [1]
[edit] History and development
Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole-ring in place of the furan-ring in ranitidine. In September 2000 Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals. [2] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA). [3] However, a year later they sold rights of the Axid Oral Solution (including the issued patent US6,930,119 protecting the product) to Braintree Laboratories.[4]
Nizatidine proved to be the last new histamine H2-receptor antagonist introduced prior to the advent of proton pump inhibitors.Not available OTC as inhibits metabolism of Warfarin.
[edit] References
- ^ Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N (January 2004). "Nizatidine for the treatment of patients with quetiapine-induced weight gain". Hum Psychopharmacol 19 (1): 37–40. doi:10.1002/hup.477. PMID 14716710.
- ^ Eli Lilly and Company and Reliant Pharmaceuticals Announce
- ^ Reliant Pharmaceuticals : Press Releases
- ^ Reliant Pharmaceuticals : Press Releases
[edit] External links
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