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NOD, Nod, or nod may refer to:
- Nod, a head.
- Nod, a fictional character from the poem "Wynken, Blynken, and Nod"
- Nod factor (nodulation factor), signaling molecules produced by rhizobia during the initiation of nodules on the root of legumes
- Nation of Domination, a former stable in the World Wrestling Federation
- Network of Disclosure, a group of comic book dealers and collectors who have pledged to disclose any form of restoration or enhancement on a comic book transferred to another party through sale, trade or gift
- Night observation device or night vision device
- Night of Decadence, a campus party at Rice University in Houston, Texas, USA
- NOD mice (non-obese diabetic mice), a strain of mice genetically prone to develop diabetes
- NOD1 and NOD2, the nucleotide-binding oligomerization domain receptors, components of the innate immune system
- NOD32, a software antivirus application from ESET software
- Notice of default, a notice given to a borrower regarding failure to pay debt
- Brotherhood of Nod, a fictional military organization in the Command & Conquer computer game series
- Nintendo optical disc, a type of media used by the Nintendo GameCube and Wii
- Nod, the original name of former Atlanta-based power pop band Raves
- Notice of Decision, a formal notice provided in response to a formal request, such as to a government entity.
- Nod, a novel from Canadian author Adrian Barnes, nominated for the 2013 Arthur C. Clarke Award
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