|Group:||Group IV ((+)ssRNA)|
Nodaviridae is a family of RNA viruses.
The virus is not enveloped and has an isocahedral capsid (triangulation number = 3) ranging from 29 to 35 nm in diameter. The capsid is constructed of 32 capsomers.
The genome is linear, positive sense, bipartite (composed of two segments - RNA1 and RNA2) single stranded RNA consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.
RNA1, which is ~3.1 kilobases in length, translates encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that translates protein B2, an RNA silencing inhibitor.
The members of the alphanodoviridae were originally isolated from insects while those of the betanodoviridae were isolated from fish. A small number of nodoviruses seem to lie outside either of these clades.
- Black beetle virus
- Boolarra virus
- Flock House virus
- Nodamura virus
- Macrobrachium rosenbergii nodavirus
- Pariacoto virus
- Penaeus vannamei nodavirus
- Tn-5 derived nodavirus
- Atlantic halibut nodavirus
- Epinephelus tauvina nervous necrosis virus
- Red-spotted grouper nervous necrosis Virus
- Sevenband grouper nervous necrosis virus
- Striped jack nervous necrosis virus
Other members include:
- Gypsy moth virus (GMV)
- Manawatu virus (MwV)
- Wuhan Nodaviru
While NoV remains the type species for this group, Flock House Virus (FHV) is the best studied of the Nodaviruses.