From Wikipedia, the free encyclopedia
Jump to: navigation, search
Virus classification
Group: Group IV ((+)ssRNA)
Family: Nodaviridae


Nodaviridae is a family of RNA viruses.


The virus is not enveloped and has an icosahedral capsid (triangulation number = 3) ranging from 29 to 35 nm in diameter. The capsid is constructed of 32 capsomers.

The genome is linear, positive sense, bipartite (composed of two segments—RNA1 and RNA2) single stranded RNA consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.

RNA1, which is ~3.1 kilobases in length, translates encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that translates protein B2, an RNA silencing inhibitor.

RNA2 encodes protein α, a viral capsid protein precursor, which is auto-cleaved into two mature proteins, a 38 kDa β protein and a 5 kDa γ protein, at a conserved Asn/Ala site during virus assembly.


The members of the alphanodoviridae were originally isolated from insects while those of the betanodoviridae were isolated from fish. A small number of nodoviruses seem to lie outside either of these clades.


  • Black beetle virus
  • Boolarra virus
  • Flock house virus (FHV)
  • Nodamura virus (NoV)
  • Macrobrachium rosenbergii nodavirus
  • Pariacoto virus
  • Penaeus vannamei nodavirus
  • Tn-5 derived nodavirus


  • Atlantic halibut nodavirus
  • Epinephelus tauvina nervous necrosis virus
  • Red-spotted grouper nervous necrosis Virus
  • Sevenband grouper nervous necrosis virus
  • Striped jack nervous necrosis virus

Other members include:

  • Covert mortality nodavirus
  • Gypsy moth virus (GMV)
  • Manawatu virus (MwV)
  • Wuhan nodavirus

While NoV remains the type species for this group, Flock house virus (FHV) is the best studied of the Nodaviruses.


External links[edit]