Nodular sclerosis
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| Nodular sclerosis | |
|---|---|
| Classification and external resources | |
 Nodular sclerosis. The distinct nodules on the cut surface of this lymph node strongly suggest the diagnosis. |
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| ICD-10 | C81.1 |
| ICD-9 | 201.5 |
| ICD-O: | M9663/3-9667/3 |
Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma[1] that is the most common subtype of HL in developed countries. It affects females and males equally and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.
The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment. [2]
[edit] References
- ^ Falchi L, Capello D, Palumbo B, et al. (November 2007). "A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy". Eur. J. Haematol. 79 (5): 455–61. doi:10.1111/j.1600-0609.2007.00952.x. PMC 2121125. PMID 17908180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2121125.
- ^ Mauch, Peter; James Armitage, Volker Diehl, Richard Hoppe, Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. p. 107. ISBN 0-7817-1502-4.
[edit] External links
- Illustration, at UMDNJ
- Illustration
- PubMed - use of Erythropoietin
- Subtypes
- Lymphoma Association information on nodular sclerosing
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