Non-stop decay

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Non-stop decay is a cellular mechanism of mRNA surveillance to detect mRNA molecules lacking a stop codon and prevent these mRNAs from translation. The non-stop decay pathway releases ribosomes that have reached the far 3' end of an mRNA and guides the mRNA to the exosome complex for selective degradation by RNase R in bacteria.[1][2]

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  1. ^ Vasudevan et al.; Peltz, SW; Wilusz, CJ (2002). "Non-stop decay--a new mRNA surveillance pathway". BioEssays 24 (9): 785–8. doi:10.1002/bies.10153. PMID 12210514. 
  2. ^ Venkataraman, K; Guja, KE; Garcia-Diaz, M; Karzai, AW (2014). "Non-stop mRNA decay: a special attribute of trans-translation mediated ribosome rescue.". Frontiers in microbiology 5: 93. doi:10.3389/fmicb.2014.00093. PMC 3949413. PMID 24653719. 

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