A 12-year-old girl with Noonan syndrome. Typical webbed neck. Double structural curve with rib deformity.
|Classification and external resources|
|OMIM||163950 605275 609942 610733 611553|
|Patient UK||Noonan syndrome|
Noonan syndrome (NS) is a relatively common autosomal dominant congenital disorder that affects both males and females.:550 It is referred to as the male version of Turner's syndrome (and is still sometimes described in this way); however, the genetic causes of Noonan syndrome and Turner syndrome are distinct. The principal features include congenital heart defect (typically pulmonary valve stenosis; also atrial septal defect and hypertrophic cardiomyopathy), short stature, learning problems, pectus excavatum, impaired blood clotting, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge. NS is a RASopathy, and is one of several disorders that are caused by a disruption of RAS-MAPK pathway signaling.
It is believed that between approximately 1 in 1,000 and 1 in 2,500 children worldwide are born with NS. It is one of the most common genetic syndromes associated with congenital heart disease, similar in frequency to Down syndrome. However, the range and severity of features can vary greatly in patients with NS. Therefore, the syndrome is not always identified at an early age.
- 1 Characteristics
- 1.1 By organ system
- 1.2 By physical appearance
- 2 Causes
- 3 Diagnosis
- 4 History
- 5 See also
- 6 References
- 7 External links
By organ system
- Individuals with NS are at elevated risk for malignant hyperthermia when receiving general anesthesia.
- Some individuals with NS have been reported to develop respiratory depression from narcotics given during and after surgery, which has sometimes required cardiac resuscitation. Impaired anesthetic clearance in the 24–48 hours after surgery has also been reported.
Up to ~85% of people with NS have one of the following heart defects:
- Pulmonary valvular stenosis (50–60%)
- Septal defects: atrial (10–25%) or ventricular (5–20%)
- Heart murmur
- Hypertrophic cardiomyopathy (12–35%)
- Restrictive lung function has been reported in some patients
- Failure to thrive From infancy to puberty (75%)
- Decreased appetite
- Digestive problems
- Frequent or forceful vomiting
- Swallowing difficulties
- Intestinal malrotation
- Need for a feeding tube
- Low gut motility
- Gastroparesis (delayed gastric emptying)
- Cryptorchidism (undescended testicles)
- Intellectual disability
- Motor development delay
- Learning disabilities
- Speech-language pathology
- Autism, pervasive developmental disorder
- Frequent illnesses, doctor appointments, pain, headaches and fatigue are a few things that can affect school attendance and performance.
- Neuropsychological testing is recommended to find strengths and challenges to tailor support needed for school, career.
- Educational customization such as an Individualized Education Program plan or a Section 504 plan is sometimes needed for school-aged children.
- Speech therapy for speech and articulation issues, physical therapy and occupational therapy for gross and fine motor delays are needed.
- Hypotonia and motor difficulties often impact handwriting. Accommodations for lessening handwriting demands will improve performance and save long term hand function.
- Bleeding disorders
- Easy bruising
- Amegakaryocytic thrombocytopenia (low platelet count)
- Blood clotting disorders
- Von Willebrand disease
- Prolonged activated partial thromboplastin time
- Partial deficiency of Factor VIII:C
- Partial deficiency of Factor XI:C
- Partial deficiency of Factor XII:C
- Platelet dysfunction
- Combined coagulation defects
- Imbalance of Plasminogen Activator Inhibitor Type-1 (PAI-1) and Tissue Plasminogen Activator (t-PA) Activity.
- Joint pain or muscle pain, with differing severity, which varies in severity
- Undifferentiated Connective Tissue Disorders with hypermobility
- Arnold-Chiari malformation (type 1), which can lead to hydrocephalus, has been noted in some patients
By physical appearance
Stature and posture
- Short stature
- Cervical (neck) spine fusion
- Prominence of breast bone (pectus carinatum)
- Depression of breast bone (pectus excavatum)
- Joint contractures or tightness
- Joint hypermobility or looseness
- Growth retardation
- Winging of the scapula
- Hypotonia (low muscle tone) and hypermobility syndrome
- Lordosis (increased hollow in the back) due to poor stomach muscle tone
- Excess skin on the back of the neck
- Low hairline at the nape of the neck
- High hairline at the front of the head
- Large head
- Triangular face shape
- Broad forehead
- Short neck, webbed neck
- Curly hair
- Hypertelorism (widely set eyes) (95%)
- Epicanthal folds (extra fold of skin at the inner corner of the eye)
- Ptosis (drooping of the eyelids)
- Proptosis (bulging eyes)
- Refractive visual errors
- Strabismus (inward or outward turning of the eyes)
- Nystagmus (jerking movement of the eyes)
- Small, upturned nose
Ears and hearing
- Low-set ears (over 90%)
- Backward-rotated ears (over 90%)
- Thick helix (outer rim) of ear(over 90%)
- Incomplete folding of ears
- Chronic otitis media (ear infections)
- Hearing loss
Mouth and speech
- Deeply grooved philtrum (top lip line) (over 90%)
- Micrognathia (undersized lower jaw)
- High arched palate
- Dental problems
- Articulation difficulties
- Poor tongue control
- Bluntly ended fingers
- Extra padding on fingers and toes
- Edema of the back of hands and tops of feet
- Cubitus valgus (elbow deformity with abnormal turning-in)
- Lymphedema (lymph swelling of the extremities)
- Keloid formation, excessive scar formation
- Hyperkeratosis (overdevelopment of outer skin layer)
- Pigmented nevi (darkly pigmented skin spots)
- Connective tissue disease
Recurrence in siblings and apparent transmission from parent to child has long suggested a genetic defect with autosomal dominant inheritance and variable expression. Mutations in the Ras/mitogen activated protein kinase signaling pathways are known to be responsible for ~70% of NS cases.
A person with NS has up to a 50% chance of transmitting it to their offspring. The fact that an affected parent is not always identified for children with NS suggests several possibilities:
- Manifestations could be so subtle as to go unrecognized (variable expressivity)
- NS is heterogeneous, comprising more than one similar condition of differing causes, and some of these may not be inherited.
- A high proportion of cases may represent new, sporadic mutations.
|Type||Online Mendelian Inheritance in Man database||Gene||Year found||Locus||% of cases||Description||Refs.|
|NS1||163950||PTPN11||2001||12q24.1||50%||The PTPN11 gene encodes the protein tyrosine phosphatase SHP-2. This protein is a component of several intracellular signal transduction pathways involved in embryonic development that modulate cell division, differentiation, and migration, including one mediated by the epidermal growth factor receptor, which is important in the formation of the semilunar heart valves.
Duplication of the chromosome region containing PTPN11 can also result in NS.
|NS2||605275||Unknown; autosomal recessive|||
|NS4||610733||SOS1||2006||2p21||10%||Activating mutations in SOS1 can give rise to NS. SHP-2 and SOS1 positively regulate the Ras/MAP kinase pathway, suggesting that its dysregulation mediates NS development.|||
NS can be confirmed genetically by the presence of any of the known mutations listed above. However, despite identification of fourteen causative genes, the absence of a known mutation will not exclude the diagnosis, as there are more, as-yet-undiscovered genes that cause NS. Thus, the diagnosis of NS is still based on clinical features. In other words, it is made when a physician feels that a patient has enough of the features to warrant the label. The principal values of making a genetic diagnosis are that it guides additional medical and developmental evaluations, it excludes other possible explanations for the features, and it allows more accurate recurrence risk estimates. With more genotype-phenotype correlation studies being performed, a positive genetic diagnosis will help the clinician to be aware of possible anomalies specific to that certain gene mutation. For example, there is an increase in hypertrophic cardiomyopathy in patients with a mutation of KRAS and an increased risk of juvenile myelomonocytic leukemia for a mutation of PTPN11. In the future, studies may lead to a targeted management of NS symptoms that depends on what genetic mutation a patient has.
Jacqueline Noonan was practicing as a pediatric cardiologist at the University of Iowa when she noticed that children with a rare type of heart defect, valvular pulmonary stenosis, often had a characteristic physical appearance, with short stature, webbed neck, wide spaced eyes, and low-set ears. Both boys and girls were affected. These characteristics were sometimes seen running in families but were not associated with gross chromosomal abnormalities. She studied 833 patients at the congenital heart disease clinic, looking for other congenital abnormalities, and in 1962 presented a paper: "Associated non-cardiac malformations in children with congenital heart disease". This described 9 children who in addition to congenital heart disease had characteristic facial features, chest deformities and short stature.
Dr. John Opitz, a former student of Dr. Noonan, first began to call the condition "Noonan syndrome" when he saw children who looked like those whom Dr. Noonan had described. Dr. Noonan produced a paper entitled "Hypertelorism with Turner Phenotype" in 1968, and in 1971 at the Symposium of Cardiovascular defects, the name 'Noonan syndrome' became officially recognized.
- Turner syndrome, a different disorder often confused with NS because of several physical features that they share
- Fetal alcohol syndrome, another disorder sometimes confused with NS because of some common facial features and mental retardation
- Other RASopathies, particularly:
- Costello syndrome
- Legius syndrome
- Noonan Syndrome with Multiple Lentigines, as known as LEOPARD syndrome, a related disorder caused by mutations in PTPN11 that are catalytically inactivating.
- Cardiofaciocutaneous syndrome, a related disorder which also affects genes encoding elements of the Ras/MAP kinase pathway.
- Speroff, Leon; Fritz, Marc A. (2005). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. https://books.google.com.ph/books?id=8sIkqPT2gh4C&pg=PA350 350]. ISBN 978-0-7817-4795-0.
- James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. ISBN 0-7216-2921-0.
- Curcić-Stojković O, Nikolić L, Obradović D, Krstić A, Radić A (1978). "[Noonan's syndrome. (Male Turner's syndrome, Turner-like syndrome)]". Med Pregl 31 (7–8): 299–303. PMID 692497.
- "Noonan syndrome" at Dorland's Medical Dictionary
- "Does Noonan Syndrome Increase Malignant Hyperthermia Susceptibility?". Malignant Hyperthermia Association of the United States. Retrieved 24 October 2014.
- "Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome.". J Pediatr Hematol Oncol 32 (7): 532–6. Oct 2010. doi:10.1097/MPH.0b013e3181e0d152. PMID 20686427.
- Reinker, Kent; Stevenson DA; Tsung A (July–August 2011). "Orthopaedic conditions in Ras/MAPK related disorders.". Journal of Pediatric Orthopeadics 31 (5): 599–605. doi:10.1097/BPO.0b013e318220396e. PMID 21654472.
- Razzaque MA, Komoike Y, Nishizawa T et al. (March 2012). "Characterization of a novel KRAS mutation identified in Noonan syndrome". Am. J. Med. Genet. A 158A (3): 524–32. doi:10.1002/ajmg.a.34419. PMID 22302539.
- Tartaglia M, Mehler EL, Goldberg R et al. (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759.
- Shchelochkov OA, Patel A, Weissenberger GM et al. (April 2008). "Duplication of chromosome band 12q24.11q24.23 results in apparent Noonan syndrome". Am. J. Med. Genet. A 146A (8): 1042–8. doi:10.1002/ajmg.a.32215. PMID 18348260.
- Van Der Burgt, I.; Brunner, H. (2000). "Genetic heterogeneity in Noonan syndrome: Evidence for an autosomal recessive form". American Journal of Medical Genetics 94 (1): 46–51. doi:10.1002/1096-8628(20000904)94:1<46::AID-AJMG10>3.0.CO;2-I. PMID 10982482.
- Schubbert S, Zenker M, Rowe SL et al. (2006). "Germline KRAS mutations cause Noonan syndrome". Nat. Genet. 38 (3): 331–6. doi:10.1038/ng1748. PMID 16474405.
- Bentires-Alj M, Kontaridis MI, Neel BG (2006). "Stops along the RAS pathway in human genetic disease". Nat. Med. 12 (3): 283–5. doi:10.1038/nm0306-283. PMID 16520774.
- Roberts AE, Araki T, Swanson KD et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
- Razzaque MA, Nishizawa T, Komoike Y et al. (2007). "Germline gain-of-function mutations in RAF1 cause Noonan syndrome". Nat. Genet. 39 (8): 1013–7. doi:10.1038/ng2078. PMID 17603482.
- De Luca, A.; Bottillo, I.; Sarkozy, A.; Carta, C.; Neri, C.; Bellacchio, E.; Schirinzi, A.; Conti, E.; Zampino, G.; Battaglia, A.; Majore, S.; Rinaldi, M. M.; Carella, M.; Marino, B.; Pizzuti, A.; Digilio, M. C.; Tartaglia, M.; Dallapiccola, B. (2005). "NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome". American Journal of Human Genetics 77 (6): 1092–1101. doi:10.1086/498454. PMC 1285166. PMID 16380919.
- Noonan, JA (1968). "Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease". Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Noonan JA. Am J Dis Child. Oct; 116 (4): 373–80. doi:10.1001/archpedi.1968.02100020377005. PMID 4386970.
- CDC. (2004). Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis. Can be downloaded at http://www.cdc.gov/fas/faspub.htm.
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