|Molar mass||218.33 g·mol−1|
|Appearance||Viscous yellow in its liquid form|
|Melting point||36 °C (97 °F; 309 K)|
|Boiling point||170 °C (338 °F; 443 K)|
|S-phrases||S23 S24 S25|
|Flash point||~ 100 °C (212 °F; 373 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Nootkatone was previously thought to be one of the main chemical components of the smell and flavour of grapefruits. In its solid form it is usually found as crystals. As a liquid, it is viscous and yellow. Nootkatone is typically extracted from grapefruit, but can also be manufactured with genetically modified organisms, or through the chemical or biochemical oxidation of valencene. It is also found in Alaska yellow cedar trees and vetiver grass.
Nootkatone in spray form has been shown as an effective repellent/insecticide against deer ticks and lone star ticks. It is also an effective repellent/insecticide against mosquitos, and may repel bed bugs, head lice and other insects. It is environmentally friendly insecticide, because it is a volatile essential oil that does not persist in the environment. It is nontoxic to humans, is an approved food additive, and "is commonly used in foods, cosmetics, and pharmaceuticals".
The CDC has licensed patents to two companies to produce an insecticide and an insect repellant. Allylix, of San Diego, CA, is one of these licensees  and has developed an enzyme fermentation process that will produce nookatone more cost effectively.
- Furusawa, Mai; Toshihiro Hashimoto; Yoshiaki Noma; Yoshinori Asakawa (November 2005). "Highly Efficient Production of Nootkatone, the Grapefruit Aroma from Valencene, by Biotransformation". Chem. Pharm. Bull. 53 (11): 1513–1514. doi:10.1248/cpb.53.1513. PMID 16272746.
- Panella, NA.; Dolan, MC.; Karchesy, JJ.; Xiong, Y.; Peralta-Cruz, J.; Khasawneh, M.; Montenieri, JA.; Maupin, GO. (May 2005). "Use of novel compounds for pest control: insecticidal and acaricidal activity of essential oil components from heartwood of Alaska yellow cedar.". J Med Entomol 42 (3): 352–8. doi:10.1603/0022-2585(2005)042[0352:UONCFP]2.0.CO;2. PMID 15962787.
- Jan Suszkiw (January 2011). "Lignin + Nootkatone = Dead Ticks". USDA.
- Dolan, MC.; Jordan, RA.; Schulze, TL.; Schulze, CJ.; Manning, MC.; Ruffolo, D.; Schmidt, JP.; Piesman, J.; Karchesy, JJ. (Dec 2009). "Ability of two natural products, nootkatone and carvacrol, to suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme disease endemic area of New Jersey". J Econ Entomol 102 (6): 2316–24. doi:10.1603/029.102.0638. PMID 20069863.
- Jordan, Robert A.; Schulze, Terry L.; Dolan, Marc C. (January 2012). "Efficacy of Plant-Derived and Synthetic Compounds on Clothing as Repellents Against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae)". Journal of Medical Entomology 49 (1): 101–106. doi:10.1603/ME10241. PMID 22308777.
- Richard Knox (April 18, 2011). "Repelling Bugs With The Essence Of Grapefruit". NPR.
- Bigelow, Bruce (2011-04-28). "Nootkatone, So A-peeling in Grapefruit, is Repellent to Mosquitoes and Ticks". xconomy.com. Retrieved 10 August 2012.
- "Cost effective fermentation replaces costly exration". Allylix. Retrieved 10 August 2012.