Norbuprenorphine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Norbuprenorphine
Norbuprenorphine.png
Systematic (IUPAC) name
(5α,6β,14β,18R)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
Clinical data
Legal status
?
Identifiers
CAS number 78715-23-8
ATC code ?
PubChem CID 6426801
ChemSpider 4932224
Chemical data
Formula C25H35NO4 
Mol. mass 413.55 g/mol

Norbuprenorphine is the main active metabolite of buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist,[1][2] and a κ-opioid receptor partial agonist.[2] It may contribute to the effects of its parent compound.[3]

See also[edit]

References[edit]

  1. ^ Yassen A, Kan J, Olofsen E, Suidgeest E, Dahan A, Danhof M (May 2007). "Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats". The Journal of Pharmacology and Experimental Therapeutics 321 (2): 598–607. doi:10.1124/jpet.106.115972. PMID 17283225. 
  2. ^ a b Huang P, Kehner GB, Cowan A, Liu-Chen LY (May 2001). "Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist". The Journal of Pharmacology and Experimental Therapeutics 297 (2): 688–95. PMID 11303059. 
  3. ^ Jensen ML, Foster D, Upton R, Grant C, Martinez A, Somogyi A (April 2007). "Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model". Xenobiotica 37 (4): 441–457. doi:10.1080/00498250701251126. PMID 17455115.