Norepinephrine-dopamine reuptake inhibitor

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A norepinephrine-dopamine reuptake inhibitor (NDRI) is a drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.[1] This in turn leads to increased extracellular concentrations of both norepinephrine and dopamine and, therefore, an increase in adrenergic and dopaminergic neurotransmission.[1]


Norepinephrine-dopamine reuptake inhibitors are used for Clinical depression, ADD, ADHD, Narcolepsy, and as antiparkinson agents.

List of NDRIs[edit]

Many NDRIs exist, including the following:

Note: Only NDRIs selective for the NET and DAT over the serotonin transporter (SERT) are listed here. For a list of NDRIs that also act at the SERT, see the SNDRI page.

Research Compounds[edit]

CA 2711977.svg
CA 2711977 
Compound 5-HT-uptake IC50(μM) DA-uptake IC50(μM) NA-uptake IC50(μM)
Piperidine-4-carboxylic (3,4-dichloro-phenyl)-ethyl-amide 0.37 0.021 0.0097
Piperidine-4-carboxylic (3-bromo-4-chloro-phenyl)-ethyl-amide 0.14 0.0078 0.005
Piperidine-4-carboxylic (3-4-dibromo-phenyl)-ethyl-amide 0.12 0.0040 0.0031
US 2011263651 
Compound 5-HT-uptake IC50(μM) DA-uptake IC50(μM) NA-uptake IC50(μM)
N-(3,4-Dichloro-phenyl)-N-ethyl-4-piperidin-4-yl-butyramide 0.57 0.012 0.030
N-(3,4-Dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide 0.80 0.0069 0.012

See also[edit]


  1. ^ a b Stephen M. Stahl (2 March 2009). Antidepressants. Cambridge University Press. p. 73. ISBN 978-0-521-75852-9. Retrieved 10 May 2012.