Normal anion gap acidosis

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Normal anion gap acidosis
Classification and external resources
ICD-10 E87.2
ICD-9 276.2
DiseasesDB 29144

In renal physiology, normal anion gap acidosis, and less precisely non-anion gap acidosis, is an acidosis that is not accompanied by an abnormally increased anion gap.

The most common etiology of normal anion gap acidosis is diarrhea with a renal tubular acidosis being a distant second.

Differential diagnosis[edit]

The differential diagnosis of normal anion gap acidosis is relatively short (when compared to the differential diagnosis of acidosis):

It can be remembered with the mnemonic HARD-UPS.[3]

As opposed to high anion gap acidosis (which involves increased organic acid production), normal anion gap acidosis involves either increased production of chloride (hyperchloremic acidosis) or increased excretion of bicarbonate.

One more commonly used older mnemonic is "USED CARP":

  • U - ureterosigmoidostomy
  • S - saline administration (in the face of renal dysfunction)
  • E - endocrine (Addisons, spironolactone, triamterene, amiloride, primary hyperparathyroidism)
  • D - diarrhea
  • C - carbonic anhydrase inhibitors
  • A - ammonium chloride
  • R - renal tubular acidosis
  • P - pancreatitis

References[edit]

  1. ^ "Metabolic Acidosis: Acid-Base Regulation and Disorders: Merck Manual Professional". Retrieved 2008-12-04. 
  2. ^ {{Citation | last1 = Vincent | first1 = Jean-Louis | last2 = Abraham | first2 = Edward | last3 = Kochanek | first3 = Patrick | title = [[Textbook of Critical Care]] | publisher = [[Elsevier]] | chapter = Acid-base disorders | date = 8 July 2011 | year = 2011 | isbn = 143771367X }}
  3. ^ Mnemonic medicalmnemonics.com 1797