|Systematic (IUPAC) name|
|Mol. mass||259.3434 g/mol|
Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine but virtually all of the opioid activity resides in the (1S,2R) isomer. The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor.
- US Patent 3792080 - Process for Substituted Cyclohexenes its Products
- J Clin Pharmacol. 2002 Nov ;42 (11):1257-61 - Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine
- Opiates: George R. Lenz page 439, Table 9-30 (78)
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