The song appears to be commenting on moral decay in society; "Like those gasping for their last breath. We cannot hide, there's nothing left" "This world was never worthy, but how can I call it 'unfaithful'? Every promise was fulfilled as decay crawled from its throat." On the album version of the song, both the clean and the screamed vocals in the chorus are sung by vocalist Tim Lambesis, but in the live video shown on Fuel TV's "The Daily Habit", drummer Jordan Mancino sings the clean lyrics. In most live shows now, bassist Josh Gilbert sings the clean part.
The video was directed by Brian Thompson. It starts as if the instrumental intro "Separation" was part of the song. It shows a dark future in which everyone who is "infected" is condemned. Several televisions throughout the video show the image of a supposed dictator with the subtitle "Condemn The Infected". The story starts with a woman who notices a mark on her neck, the mark of the infected. She wears a scarf to conceal the mark, but the scarf is removed later on. Consequently, several people notice and point their fingers at her. The dictator arrives on the scene and takes her to the ancient Roman Colosseum. At the Colosseum, she is stripped of her clothing and humiliated in front of thousands of spectators. She is then taken from the Colosseum and led to the edge of a cliff, where the video ends. The video for "The Sound of Truth" continues this story. The story continues with a rebellion of infected people being formed (against the supposed dictator) and two infected men rescuing the woman and donning the suits of the two soldiers who were about to throw her off the cliff. The two men go to the room where the supposed dictator is controlling the televisions that he is seen on and capture him. The end of the video shows people screaming for the dictator to be punished. The dictator is thrown on the ground and calls for help but the people continue screaming. The dictator's black leather gloves are then thrown off and the people stop screaming when they see that he is infected, and the video ends. The video for "Nothing Left" is intercut with shots of the band performing in a room with computers, while the video for "The Sound of Truth" shows the band performing on top of a building downtown in a storm.